The Answer: No. While major hotels, restaurants, and tour operators in cities like Lima, Santiago, and La Paz accept cards, cash is king the moment you step outside urban centers.
Local Tip: Keep small denominations of the local currency (Soles, Bolivianos, or Chilean Pesos) for market vendors, taxis, and public restrooms. Ensure any US dollars you bring for exchange are crisp, unripped, and unblemished—many exchanges will reject bills with minor tears.